Research Information Only — This page explains how our content is produced; it is not medical advice.
Editorial Methodology · E-E-A-T Standards

How We Research, Grade, and Correct This Site

Anyone can publish a peptide "guide." What's rare is a peptide reference that tells you exactly how it decides what to say, admits where the evidence is thin, and shows its work when it's wrong. This page is that disclosure — the same standard we'd want if we were reading someone else's site.

Four Non-Negotiable Standards

Every page on PeptideReport.ai — every hub, every compound profile, every guide — is built against the same four standards before it publishes.

01

Named Physician Authorship

Every page carries a real byline — Dr. Scott DelBoccio, DMD — not an anonymous "editorial team." Credentials are stated accurately; we never claim "MD" when the credential is "DMD."

02

Graded, Not Assumed, Evidence

Every claim about efficacy or safety is tied to a stated evidence level. "Some studies suggest" is not an acceptable substitute for naming the study, the population, and the sample size.

03

Regulatory Honesty

FDA-approved, foreign-approved, and investigational-only are stated in plain language on every page — with the jurisdiction named, not implied.

04

No Commercial Conflict

This site does not sell peptides, does not link to vendors or sourcing pages, and has no affiliate relationship with any compounding pharmacy or supplier.

What We Cite — and What We Don't

Every factual claim on this site traces back to one of the source types below. Marketing copy, forum anecdotes, and unverified vendor claims are never used as a primary source, though we do reference them when explicitly correcting a misconception that has spread through them.

Source TypeUsed As Primary Evidence?Example
Peer-reviewed RCTs & systematic reviewsYes — highest weightCochrane Database of Systematic Reviews; NEJM; JCEM
Regulatory filings & labelsYesFDA NDA/label text; EMA; Russian Ministry of Health approvals
Peer-reviewed mechanism/preclinical studiesYes — labeled as preclinicalJ Pharmacol Exp Ther; Neuroscience and Behavioral Physiology
Government/regulatory advisory proceedingsYesFDA Pharmacy Compounding Advisory Committee minutes
Vendor marketing & product pagesNoReferenced only to identify and correct a specific spreading error
Forum posts & anecdotal reportsNoNever cited as evidence of efficacy or safety
Uncited "some studies show" claimsNoIf we can't name the study, we don't make the claim

Our Four-Tier Evidence Level System

Adapted from the Oxford Centre for Evidence-Based Medicine hierarchy for the realities of peptide research — where regulatory approval outside the US is common and needs its own honest framing rather than being treated as equivalent to, or dismissed relative to, FDA approval.

I

FDA-Approved, or Cochrane Systematic Review Exists

The highest tier available in peptide research. Note: a Cochrane review existing does not mean its finding is favorable — Level I means the evidence quality is high, not that the result flatters the compound. We report the actual finding either way.

Ib

Single CONSORT-Compliant Western RCT

One well-designed, randomized, controlled trial from a Western regulatory context, without an accompanying systematic review.

IIb

Phase I/II Surrogate Data, or Russian/Eastern European Phase II/III

Meaningful human trial data exists, but either the endpoints are surrogate markers rather than clinical outcomes, or the pivotal trials were conducted under a non-Western regulatory framework without independent Western replication.

V

Preclinical Only

Rodent, in vitro, or mechanistic data exists, but no controlled human trial has been published. We say so explicitly — "no human safety data" rather than "limited human data" when the honest answer is zero.

Our Research & Publication Process

Content on this site is produced with the assistance of AI research and drafting tools, working from primary-literature research — never from vendor copy or a competitor's page — with every draft reviewed and edited under Dr. DelBoccio's physician judgment before it publishes. We disclose this plainly because pretending otherwise would violate the honesty standard this whole site is built on.

1

Primary literature is gathered first

Before any page is drafted, the relevant peer-reviewed studies, regulatory filings, and systematic reviews are identified and read — including checking whether a commonly repeated claim about the compound is actually supported by the source it's attributed to.

2

Evidence is graded before it's written up

Each compound is assigned its evidence level (I through V) based on the sourcing standards above — this determines the tone of the page before a word of copy is written, so the writing never gets ahead of the evidence.

3

Common online misconceptions are checked against the primary source

Where a compound has a widely repeated claim circulating in vendor or forum content, we trace it back to its origin. If the claim doesn't hold up — a misattributed study, an outdated regulatory status, a fabricated citation — we correct it explicitly on the page rather than silently omitting it.

4

Physician review before publication

Dr. DelBoccio reviews every page for clinical accuracy, compliance framing (education never prescription, no disease-cure claims, regulatory status stated plainly), and editorial tone before it goes live.

5

Pages are living documents

When new literature is published, a regulatory status changes, or an error is identified — by us or by a reader — the page is updated in place. See our correction policy below.

Our Correction Policy

We would rather be visibly wrong once and fix it than quietly leave an error standing. Recent examples of corrections made on this site:

Pinealon retinal-ischemia misattribution corrected. A claim commonly repeated online — that Pinealon has evidence in retinal ischemia models — was traced to a different, related compound (Epithalon). Corrected across the Cognitive Hub and the Pinealon profile.
Cerebrolysin evidence framing rebalanced. An earlier version of the Cognitive Hub described Cerebrolysin's evidence base as unambiguously the strongest and safest in the hub. Updated to include the 2023 Cochrane review's actual headline finding — no mortality benefit and roughly doubled serious-adverse-event risk in acute ischemic stroke — alongside the more favorable subgroup data.
Fabricated citation identified and named. A "2024 Psychoneuroendocrinology" study connecting PT-141 and oxytocin, found circulating in vendor marketing, does not appear to exist. Rather than silently avoiding it, our Oxytocin profile names and debunks it directly.

What You Should Know Before Trusting Us

Single-Author Site

PeptideReport.ai is currently authored and reviewed by one physician, Dr. Scott DelBoccio, DMD. We are not a multi-physician editorial board, and we say so rather than implying broader institutional review than actually exists.

DMD, Not MD

Dr. DelBoccio's credential is a Doctor of Dental Medicine (DMD), not a Doctor of Medicine (MD). This is stated accurately in every schema.org author block and byline on this site — we do not permit "MD" to appear anywhere in reference to this author, in either direction of ambiguity.

No Compensation From Any Compound, Vendor, or Clinic

This site carries no advertising, no affiliate links, and no paid placement for any compound, compounding pharmacy, or clinic. If that ever changes, this page will be updated to disclose it before the change takes effect.

Methodology FAQ

Is this site written entirely by a human?

Content is drafted with AI research and writing assistance, working from primary literature, and reviewed and edited under physician judgment before publication. We disclose this because a site built on evidence honesty should apply the same honesty to how it's produced.

Does a dentist have any business writing about peptide pharmacology?

Dr. DelBoccio's degree is a DMD, and we state that plainly rather than implying a broader medical credential. His focus is peptide pharmacology and longevity medicine research — see the full bio for background. Readers should always weigh a source's actual credentials, which is exactly why we state ours precisely instead of rounding up.

How often is content updated?

Pages are revisited when new primary literature is published, when a regulatory status changes (an FDA advisory vote, a nomination withdrawal, a new approval), or when an error is identified. There is no fixed calendar — the trigger is new information, not a schedule.

Can I report an error?

Yes — see the About page for contact information. Reader-identified corrections are treated the same as internally identified ones: fixed in place, and where material, disclosed here.

SD

Dr. Scott DelBoccio, DMD

Founder, Author & Physician-Reviewer · PeptideReport.ai

Dr. DelBoccio wrote this methodology page himself, applying the same standard to PeptideReport.ai's own process that the site applies to every compound it covers. Read his full biography.


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